Although further studies are required to elucidate the mechanism behind this phenomenon, the alterations described here may represent a novel biomarker candidate panel in IBS that is especially needed given the current reliance on a symptom-based diagnostic scheme. The authors would like to acknowledge Dr. Sandra Barry, Ms. Neasa O'Leary, Mr. Srinivas Suda, and Mr. David Russell for their contributions to the study.
Previous Section Next Section. Subjects Female patients were recruited from a university database of IBS patients.
Trial protocol A total of 67 subjects, 41 patients with IBS and 26 healthy, sex-matched controls of comparable age and BMI, gave fully informed consent to take part in this study, which had local ethics committee approval. Assessments On arrival at the clinical investigation laboratory at Sample collection Whole blood was collected at Eicosanoid analysis PGE 2 and LTB 4 were measured in serum from a reduced subject group of the trial subjects outlined above.
View this table: In this window In a new window. TABLE 1. Arachidonic acid levels Plasma AA concentrations were significantly elevated in IBS patients compared with controls 8. Previous Section. Ersryd A. Medline Google Scholar. Quigley E. Changing face of irritable bowel syndrome. World J.
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